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SINDOLOR GEL -
WITHOUT PAIN, IT’S ALWAYS A PLEASURE!
 
COMPOSITION
1 gram gel contains piroxicam 5 mg, lidocaine 20 mg, cyclobenzaprine hydrochloride 5 mg. Other ingredients: carbopol 980, triethanolamine, d-panthenol, ethanol 96%, propylene glycol, methyl p-hydroxybenzoate, propyl p-hydroxybenzoate, purified water.

THERAPEUTIC INDICATIONS
SINDOLOR, gel  is indicated in the treatment of inflammatory or post-traumatic diseases of joints and soft tissues:

  • muscle contractions (e.g. torticollis)
  • sprains
  • contusions
  • different inflammatory/post-traumatic diseases of joints/soft tissues
CONTRAINDICATIONS
  • hipersensitivity to piroxicam, acetylsalicylic acid, other NSAIDs, lidocaine, cyclobenzaprine hydrochloride or any of the ingredients;
  • if you ever had asthma attacks, nasal polyposis, soft tissue swelling at the level of face or neck or rash induced by acetylsalicylic acid or other NSAIDs;
  • the 3rd trimester of pregnancy.
WARNINGS
Patients must take special care when using high doses of SINDOLOR, gel , if they are currently dealing with or have a history of stomach and intestine disorders, heart or kidney diseases, clotting problems, glaucoma, urinary retention or in case of dehydration.

Appropriate care must also be taken if you are presently having or had asthma attacks, allergic rhinitis, nasal polyposis, chronic sinusitis.

SINDOLOR, gel  must not be applied on mucous membranes, at the level of eyes, on large skin areas, on skin lesions, or on areas covered with occlusive dressings/ body tight clothing.

DOSAGE AND ADMINISTRATION
SINDOLOR, gel  is administered in adults and children over 15 years old. The gel is applied at the level of the painful skin area, by gently rubbing until complete penetration; the recommended dose is 0.5-1.0 g gel (about 3-4 cm), applied twice daily. The duration of treatment depends on the affection type and clinical evolution of the disease.

RECOMMENDATIONS
Read the leaflet before use.
Keep out of reach and sight of children.
Store at temperatures below 25ºC, in original package.
Do not use after the expiration date printed on the secondary package.
Without medical prescription.

PRESENTATION
  • Cardboard box containing 1 aluminum tube with 25 g gel.
  • Cardboard box containing 1 aluminum tube with 45 g gel.

FOR ADDITIONAL INFORMATION REGARDING SINDOLOR GEL PLEASE READ THE LEAFLET.
Download Leaflet from here.
HOW DOES SINDOLOR WORK?
 
SINDOLOR, gel  has a complex mechanism of action, acting by hindering the sensitivity of nociceptors and by inhibiting the transmission of the nociceptive information to brain.
  • Inhibits the pro-inflammatory prostaglandin synthesis and consequently the effects of the inflammatory process: pain and edema

  • Inhibits the nerve impulse transmission by blocking sodium channels and hinders the local effect of adenosine and serotonin (neurotransmitters involved in „pain” signaling)

  • Reduces the pain signal transmission;
  • Lowers the pain sensitivity.
NEWSLETTER
ABOUT NOCICEPTION
 
Musculoskeletal pain appears consequently to an inflammation, spasm or muscular contraction.

In order to treat the musculoskeletal pain with topical products, the most frequently used products are those containing non-steroidal anti-inflammatory drugs (so called “anti-rheumatic and analgesic drugs” - NSAIDs). These products act by hindering the prostaglandin synthesis, substances that cause inflammation and pain. The best known and used NSAIDs are: piroxicam, diclofenac, ketoprofen, or ibuprofen.

Frequently, the single administration of an anti-inflammatory drug does not lead to the predicted pharmacological effect, the pain sensitivity persisting for a higher period of time than expected until the analgesic effect is settled. This happens because the NSAIDs only inhibit the new prostaglandin synthesis, but do not hinder the already formed prostaglandins responsible for the residual pain and inflammation.

For a clearly improved effect, the topical applied anti-inflammatory drug is combined with a topical anaesthetic (usually lidocaine). The anaesthetic acts by decreasing the pain sensitivity, without having an anaesthetic effect, but only an analgesic one (e.g. the motor function remains undamaged). Therefore, even if the already synthesized prostaglandins exert their pro-inflammatory effect, nociceptive sensation is much diminished.

This type of association between 2 categories of analgesic drugs that act through different mechanisms simultaneously fights against the processes that initiate pain and also against the processes of pain transmission and perception. The final result consists of faster improvement, rehabilitation, and decrease of pain sensitivity.
CONTACT INFORMATION
 

CONTACT INFORMATION

London

127 Pacurari Rd. (Pacurari Round point), Iasi, 700544

EMAIL: office@fitermanpharma.ro

Tel/Fax: +40 232.252.800

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